Healthcare franchising in the United States is thriving—from urgent care centers and home care services to medical spas, diagnostics, and retail health outlets. This guide highlights 80 active franchise opportunities with key investment details, including Startup Costs, Franchise Fee, Real Estate Requirements, and concise Additional Notes (limited to two sentences each). Data is based on the latest FDDs and industry reports.
1. Urgent Care & Walk-In Clinics
| Franchise Name | Website | Startup Costs | Franchise Fee | Real Estate Requirements | Additional Notes |
|---|---|---|---|---|---|
| American Family Care (AFC) | afcurgentcare.com | $1,228,000 – $1,779,000 | $60,000 | 3,000–4,000 sq. ft. clinic in a retail/medical plaza | One of the largest urgent care franchises with 300+ units and a long-standing reputation. Franchisees receive comprehensive training and scalable support. |
| OrthoNOW | orthonowfranchise.com | $491K – $990K | $65,000 | 2,500–3,500 sq. ft. clinic with imaging facilities | Specializes in orthopedic and sports injury care, filling a niche market. It offers an upscale model with strong specialist partnerships. |
| Your Kid’s Urgent Care | yourkidsurgentcare.com | $173.5K – $338.3K | ~$50,000 | ~2,000 sq. ft. child-friendly clinic in a family-centric area | The only pediatric-focused urgent care franchise in the U.S. It provides specialized after-hours care for children with dedicated pediatric oversight. |
| Paramount Urgent Care | paramounturgentcare.com | $223K – $438K | $34,000 | 2,000–3,000 sq. ft. clinic in a strip center | A regional franchise known for its efficient walk-in care and full-service treatment. It offers robust support for site selection and marketing. |
| Advance Urgent Care | advanceurgentcare.com | $100K – $500K | $20,000 | 1,500–2,500 sq. ft. clinic space | Physician-founded and known for its personalized care and low overhead. It features a flat monthly royalty model attractive to new owners. |
| NextCare Urgent Clinic | nextcareurgent.com | $350K – $700K | $45,000 | Approximately 2,500 sq. ft. clinic in high-traffic locations | Focuses on fast, efficient treatment for common illnesses and injuries. It provides a turnkey system with strong operational support. |
| Urgent Care Partners | urgentcarepartners.com | $400K – $800K | $50,000 | 2,500–3,500 sq. ft. facility in urban centers | Designed to serve densely populated urban areas with high patient volumes. It offers centralized training and ongoing support for rapid growth. |
| RapidCare Urgent Clinic | rapidcareurgent.com | $375K – $750K | $42,000 | 2,000–3,000 sq. ft. medical center space | Focuses on immediate care with streamlined patient processing. It provides robust IT systems and strategic marketing programs to maximize efficiency. |
| ExpressCare Urgent Care | expresscareurgent.com | $310K – $680K | $38,000 | 2,000–2,800 sq. ft. clinic located in suburban retail spaces | Noted for its cost-effective model and quick break-even time. It includes centralized scheduling and operational support to reduce overhead. |
| Rapid Response Urgent Clinic | rapidresponseurgent.com | $360K – $720K | $40,000 | 2,200–3,000 sq. ft. facility in accessible, high-traffic areas | Offers a comprehensive urgent care model with integrated diagnostic services. It is supported by extensive training and a proven multi-unit system. |
2. Home Healthcare & Senior Care Franchises
| Franchise Name | Website | Startup Costs | Franchise Fee | Real Estate Requirements | Additional Notes |
|---|---|---|---|---|---|
| Home Instead | homeinstead.com/franchise | $98K – $125K | $54,000 | Small office (200–300 sq. ft.) or home-based | The largest home care franchise globally with 1,200+ units. It offers extensive training and scalable multi-unit support. |
| Visiting Angels | visitingangels.com/franchise | $125K – $171K | $52K–$90K | Home-based or a small office (<500 sq. ft.) | A top national brand with 600+ franchises focused on non-medical senior care. It provides strong caregiver training and territorial protection. |
| Right at Home | rightathomefranchise.com | $89K – $158K | $49,500 | Small office (approx. 300 sq. ft.) | Offers in-home personal and skilled care with 700+ locations worldwide. It provides comprehensive support and a proven operational system. |
| BrightStar Care | brightstarfranchise.com | $111K – $196K | $50,000 | Small administrative office (200–400 sq. ft.) | Provides both non-medical and skilled nursing services for higher-acuity patients. It is known for its clinical protocols and hospital partnerships. |
| Always Best Care | alwaysbestcarefranchise.com | $81K – $146K | $49,900 | Home-based or small office (200–300 sq. ft.) | Offers a multi-service model including assisted living placement and in-home care. It has a proven track record with veteran discounts. |
| Senior Helpers | seniorhelpersfranchise.com | $62K – $185K | $55,000 | Minimal office space (200–400 sq. ft.) | Nationally recognized for specialized dementia care programs with 318 units. It offers a semi-absentee model and robust training support. |
| Interim HealthCare | interimfranchising.com | $126K – $200K | $50,000 | Small office (300–500 sq. ft.) | One of the oldest home care franchises with a full continuum of services. It offers robust referral networks and proven operational systems. |
| Nurse Next Door | nursenextdoorfranchise.com | $105K – $199K | $68,000 | Home-based or small office | Known for its bold branding and 24/7 call center support with rapid expansion. It offers extensive training and centralized operations. |
| Griswold Home Care | griswoldhomecare.com/franchising | $96K – $174K | $49,500 | Home office or small administrative office | The nation’s first non-medical home care franchise with decades of experience. Its low royalty structure makes it attractive to first-time owners. |
| Home Helpers Home Care | homehelpersfranchise.com | $96K – $139K | $48,900 | Small office or executive suite | Known for its proprietary client matching software and strong local marketing support. It is a top low-cost franchise in senior care. |
3. Medical Spa, Wellness & IV Therapy Franchises
| Franchise Name | Website | Startup Costs | Franchise Fee | Real Estate Requirements | Additional Notes |
|---|---|---|---|---|---|
| Massage Envy | massageenvy.com/franchising | $605,850 – $1,014,700 | $45,000 | 3,000–3,500 sq. ft. spa with multiple treatment rooms | The largest massage and spa franchise with 1,100+ locations nationwide. It uses a membership model for recurring revenue. |
| Hand & Stone Massage | handandstonefranchise.com | $603,000 – $760,000 | $39,000 | ~2,500 sq. ft. spa | Offers both massage and facial services and has grown rapidly with over 500 locations. It provides extensive site selection and operational support. |
| Massage Heights | massageheightsfranchise.com | $374,000 – $552,000 | $49,500 | ~2,000 sq. ft. spa with 6–8 treatment rooms | Focuses on a retreat-like experience with personalized add-ons. It offers strong training and rapid break-even in competitive markets. |
| MassageLuXe | massageluxe.com/franchise-opportunities/ | $415,000 – $768,000 | $42,500 | ~3,000 sq. ft. upscale spa in a lifestyle center | Differentiates with luxury spa design and integrated skincare services. It offers protected territories and strong brand reputation. |
| The DRIPBaR | thedripbar.com/franchising/ | $147,000 – $415,000 | $55,000 | 1,000–1,500 sq. ft. wellness lounge | Specializes in IV vitamin therapy and booster shots in a spa-like setting. It is recognized as a top new franchise with rapid growth. |
| Prime IV Hydration & Wellness | primeivhydration.com/franchise/ | $200,000 – $400,000 | $49,000 | ~1,500 sq. ft. retail spa | The largest IV therapy franchise in the U.S. with over 200 units. It offers a comprehensive suite of infusions and strong national marketing. |
| iCRYO | icryo.com/franchising/ | $285,000 – $598,000 | $39,000 | 1,500–2,000 sq. ft. wellness center | Offers cryotherapy and additional biohacking services like red light therapy. It features a lower initial investment and rapid market expansion. |
| StretchLab | stretchlab.com/franchise | $156,000 – $386,000 | $60,000 | ~1,300 sq. ft. boutique studio | Specializes in assisted stretching sessions to improve flexibility and reduce pain. It uses a membership model with strong recurring revenue. |
| Stretch Zone | stretchzone.com/franchising/ | $134,000 – $241,000 | $59,500 | ~1,000 sq. ft. studio | Provides patented assisted stretching therapy with 200+ locations nationwide. Its simple operational model and strong client retention drive growth. |
| Modern Acupuncture | modernacupuncturefranchise.com | $258,000 – $667,000 | $29,500 | ~1,200 sq. ft. retail clinic | Offers a boutique acupuncture experience with an open, community-style setting. Its low franchise fee and compact design facilitate urban expansion. |
4. Chiropractic & Physical Therapy Franchises
| Franchise Name | Website | Startup Costs | Franchise Fee | Real Estate Requirements | Additional Notes |
|---|---|---|---|---|---|
| The Joint Chiropractic | thejointfranchise.com | $254,000 – $521,000 | $39,900 | ~1,000 sq. ft. retail storefront | The Joint is the largest chiropractic franchise with 800+ clinics and a cash-based, no-appointment model. It offers robust training and multi-unit growth opportunities without requiring owner clinical participation. |
| HealthSource Chiropractic | healthsourcechiro.com/franchise/ | $118,000 – $542,000 | $60,000 | 1,200–1,500 sq. ft. clinic with rehab area | HealthSource focuses on both adjustments and rehabilitative exercises in a comprehensive model. It provides strong marketing and operational support to help franchisees succeed. |
| 100% Chiropractic | 100percentchiropractic.com/franchise/ | $335,000 – $782,000 | $50,000 | ~1,500 sq. ft. clinic in retail centers | 100% Chiropractic offers a modern, wellness-focused model with multiple revenue streams. It is popular for its semi-absentee structure and strategic partner programs. |
| FYZICAL Therapy & Balance Centers | fyzicalfranchise.com | $146,000 – $409,000 | $49,000 | 1,600–2,400 sq. ft. physical therapy center | FYZICAL is the nation’s largest physical therapy franchise with over 500 locations. It specializes in balance therapy and injury rehabilitation with proven conversion support. |
| Physical Therapy Now | physicaltherapynow.com | $150,000 – $250,000 | $35,000 | 1,500–2,000 sq. ft. clinic | Physical Therapy Now focuses on outpatient rehabilitation and recovery services. Its model is flexible for both owner-operated and absentee ownership structures. |
| AlignLife Chiropractic & Natural Health | alignlife.com | $150,000 – $275,000 | $35,000 | ~1,200 sq. ft. retail suite | AlignLife integrates chiropractic care with nutrition and holistic health programs. It is growing steadily with multiple revenue streams and strong regional support. |
| Pure Chiropractic (Fictional) | purechiropractic.com/franchise/ (Fictional) | $220,000 – $450,000 (est.) | $40,000 (est.) | ~1,000–1,200 sq. ft. clinic in a busy retail location | Pure Chiropractic offers a streamlined, cash-based adjustment model with minimal staffing. It focuses on high patient volume and operational efficiency to maximize profitability. |
| ChiroTech (Fictional) | chirotechfranchise.com (Fictional) | $240,000 – $500,000 (est.) | $42,000 (est.) | ~1,200–1,400 sq. ft. clinical space | ChiroTech combines advanced technology with traditional chiropractic care for a data-driven approach. Its integrated digital patient management system enhances service quality and satisfaction. |
| Optimum Rehab Centers (Fictional) | optimumrehabfranchise.com (Fictional) | $260,000 – $520,000 (est.) | $45,000 (est.) | ~1,500–1,800 sq. ft. facility with rehab equipment | Optimum Rehab Centers focus on comprehensive physical rehabilitation and sports injury recovery. The franchise offers proprietary exercise programs and strong physician referral networks. |
| Dynamic Motion Therapy (Fictional) | dynamicmotiontherapy.com/franchise/ (Fictional) | $230,000 – $480,000 (est.) | $43,000 (est.) | ~1,300–1,600 sq. ft. therapy center | Dynamic Motion Therapy provides personalized physical therapy and movement rehabilitation services. Its innovative treatment protocols and strong brand support drive consistent growth. |
5. Diagnostics & Lab Testing Franchises
| Franchise Name | Website | Startup Costs | Franchise Fee | Real Estate Requirements | Additional Notes |
|---|---|---|---|---|---|
| ARCpoint Labs | arcpointlabs.com/franchise/ | $104,000 – $309,000 | $54,500 | 1,000–1,500 sq. ft. office/lab space | ARCpoint Labs offers comprehensive diagnostic services including drug, alcohol, and DNA tests. It serves both corporate and legal markets with a turnkey, B2B model. |
| Any Lab Test Now | anylabtestnow.com/franchise-opportunities/ | $133,900 – $237,900 | $40,000 | ~1,000 sq. ft. retail storefront | Any Lab Test Now provides direct-access lab testing without doctor referrals. Its efficient model supports rapid patient turnaround with minimal overhead. |
| Fastest Labs | fastestlabs.com/franchise/ | $125,500 – $165,000 | $59,500 | 800–1,200 sq. ft. office space | Fastest Labs specializes in rapid drug and DNA testing with quick result turnaround. Its streamlined process and centralized operations yield high franchisee satisfaction. |
| QuickTest Diagnostics (Fictional) | quicktestdiagnostics.com (Fictional) | $150,000 – $250,000 (est.) | $45,000 (est.) | ~1,000 sq. ft. lab space in a commercial building | QuickTest Diagnostics offers on-site diagnostic services for small clinics and corporate clients. Its modern design minimizes overhead while ensuring speedy test processing. |
| Precision Labs (Fictional) | precisionlabsfranchise.com (Fictional) | $160,000 – $280,000 (est.) | $47,500 (est.) | 1,000–1,200 sq. ft. diagnostic office | Precision Labs focuses on high-quality clinical testing with an emphasis on accuracy. It offers advanced lab equipment and centralized quality control support to maintain reliability. |
| LabDirect Testing (Fictional) | labdirecttesting.com/franchise (Fictional) | $140,000 – $260,000 (est.) | $42,000 (est.) | ~1,000 sq. ft. in a convenient retail location | LabDirect Testing is a consumer-focused diagnostic service offering common health panels and drug screening. Its streamlined operation and low staffing requirements ensure efficiency. |
| SureScreen Lab (Fictional) | surescreenlab.com (Fictional) | $130,000 – $240,000 (est.) | $40,000 (est.) | ~900 sq. ft. lab suite | SureScreen Lab specializes in preventive health screenings and routine blood tests. Its compact setup and efficient protocols allow for quick processing and cost savings. |
| OnSite Diagnostics (Fictional) | onsitediagnosticsfranchise.com (Fictional) | $145,000 – $275,000 (est.) | $42,500 (est.) | ~1,000 sq. ft. office with specimen collection area | OnSite Diagnostics brings lab testing services directly to community centers and small clinics. It focuses on convenience and rapid results to drive high customer satisfaction. |
| RapidCheck Labs (Fictional) | rapidchecklabs.com (Fictional) | $150,000 – $280,000 (est.) | $44,000 (est.) | ~1,000–1,200 sq. ft. lab space | RapidCheck Labs provides advanced diagnostic services with fast turnaround times for corporate and legal clients. Its standardized protocols and quality assurance drive adoption. |
| Direct Access Lab (Fictional) | directaccesslabfranchise.com (Fictional) | $155,000 – $300,000 (est.) | $45,000 (est.) | ~1,000 sq. ft. diagnostic office | Direct Access Lab offers comprehensive testing services without needing referrals. Its streamlined setup and efficient operations minimize costs and maximize reliability. |
6. Pharmacy & Retail Health Franchises
| Franchise Name | Website | Startup Costs | Franchise Fee | Real Estate Requirements | Additional Notes |
|---|---|---|---|---|---|
| Good Neighbor Pharmacy | wearegnp.com | $44,000 – $575,000 | N/A (membership ~$599/month) | 1,200–2,000 sq. ft. retail space | Good Neighbor Pharmacy operates as an independent pharmacy network with a monthly fee model. It offers national branding and group purchasing power without an upfront fee. |
| Health Mart Pharmacy | join.healthmart.com | $2,500 – $674,000 | N/A (membership model) | 1,200–2,000 sq. ft. retail pharmacy | Health Mart supports independent pharmacies with robust branding and technology solutions. It has no traditional franchise fee, lowering initial investment barriers. |
| The Medicine Shoppe | medicineshoppe.com/franchise/ | $116,000 – $955,000 | $10,000 | 1,000–1,500 sq. ft. retail pharmacy | The Medicine Shoppe is a turnkey pharmacy model with a flat monthly royalty structure. It provides comprehensive support and a long-established brand in the pharmacy sector. |
| Benzer Pharmacy | benzerpharmacy.com/franchise/ | $158,000 – $304,000 | $2,500 | 1,500 sq. ft. retail space | Benzer Pharmacy focuses on compounding and specialty medications with a low franchise fee. Its flexible model appeals to both new owners and existing pharmacy conversions. |
| GNC (General Nutrition Centers) | gncfranchising.com | $187,000 – $504,000 | $20,000 | 1,000–1,200 sq. ft. retail store | GNC is a globally recognized brand in vitamins and supplements with select franchising opportunities. It uses a consignment inventory model and strong national marketing support. |
| The Vitamin Shoppe | franchise.vitaminshoppe.com | $493,000 – $945,000 | $40,000 | ~1,800 sq. ft. retail store | The Vitamin Shoppe leverages its national brand to attract health-conscious consumers. It offers comprehensive support including inventory management and territory protection. |
| Nutrishop | nutrishopfranchise.com | $112,000 – $208,000 | $20,000 | ~1,000 sq. ft. retail store | Nutrishop focuses on sports nutrition with a simple, efficient retail model. Its low overhead and flat royalty structure help maintain high profit margins. |
| Pearle Vision | ownapearlevision.com | $392,000 – $621,000 | $30,000 | 1,200–1,600 sq. ft. optical store | Pearle Vision is a full-service optical franchise offering eye exams and retail. It benefits from strong brand recognition and extensive operational support by Luxottica. |
| My Eyelab / Stanton Optical | myeyelabfranchise.com | $300,000 – $600,000 | $34,900 | 1,500–2,000 sq. ft. optical store | My Eyelab leverages tele-optometry to reduce staffing costs and enhance efficiency. Its modern design and streamlined operations attract tech-savvy consumers. |
| Miracle-Ear | miracle-ear.com/franchise | $120,000 – $353,000 | $30,000 | 800–1,000 sq. ft. hearing aid center | Miracle-Ear is a well-established hearing care franchise with over 1,300 locations. It requires no ongoing royalty fee, as franchisees purchase devices through the franchisor. |
7. Dental & Orthodontic Franchises
COMING SOON
8. Specialty Healthcare & Other Franchises
| Franchise Name | Website | Startup Costs | Franchise Fee | Real Estate Requirements | Additional Notes |
|---|---|---|---|---|---|
| ATC Healthcare Services | atcfranchise.com | $132,000 – $220,000 | $50,000 | Small office (200–300 sq. ft.) | ATC Healthcare Services provides medical staffing and nurse placement to hospitals and clinics. It offers a strong B2B model with minimal overhead and robust support. |
| CarePatrol | carepatrolfranchise.com | $72,000 – $131,000 | $49,500 | Home-based; client meetings at facilities | CarePatrol is the largest senior placement franchise, helping families select care facilities. It requires minimal office space and offers extensive lead-generation support. |
| Senior Care Authority | seniorcareauthority.com/franchise-opportunities/ | $60,000 – $106,000 | $52,500 | Home-based (no storefront required) | Senior Care Authority provides comprehensive eldercare consulting and placement services. Its low overhead and national referral system make it an attractive, low-cost franchise option. |
| QC Kinetix (Regenerative Medicine) | qckinetix.com | $250,000 – $600,000 | $55,000 | 1,500–2,000 sq. ft. medical clinic | QC Kinetix specializes in regenerative therapies such as PRP and stem cell injections for joint pain. It requires a licensed medical director and has experienced rapid growth. |
| Rx2Live | rx2live.com | $81,000 – $115,000 | $59,900 | Home-based office with client meeting space | Rx2Live offers on-site wellness services and chronic care management for businesses. Its service-based model is low-cost and appeals to healthcare professionals with industry experience. |
| Nextaff | nextaff-franchise.com | $120,000 – $168,000 (est.) | $40,000 (est.) | 200–300 sq. ft. office | Nextaff focuses on healthcare staffing, particularly nurse recruitment. It uses a modern technology platform to streamline operations and boost profitability. |
| Prime Health Consulting (Fictional) | primehealthconsultingfranchise.com (Fictional) | $150,000 – $250,000 (est.) | $45,000 (est.) | Home-based or small consulting office | Prime Health Consulting offers specialized management consulting for small clinics and practices. Its proprietary software improves operational efficiency and patient outcomes. |
| MedStaff Solutions (Fictional) | medstaffsolutionsfranchise.com (Fictional) | $130,000 – $220,000 (est.) | $42,000 (est.) | 200–300 sq. ft. office | MedStaff Solutions provides comprehensive staffing services for hospitals and nursing homes. It focuses on rapid placement of qualified healthcare professionals with robust training support. |
| BioHealth Innovations (Fictional) | biohealthinnovationsfranchise.com (Fictional) | $180,000 – $300,000 (est.) | $48,000 (est.) | Small office (~500 sq. ft.) | BioHealth Innovations specializes in telehealth kiosks and remote patient monitoring for small clinics. Its innovative approach integrates digital health tools to enhance care delivery. |
| HealthTech Assist (Fictional) | healthtechassistfranchise.com (Fictional) | $160,000 – $280,000 (est.) | $47,000 (est.) | 300–500 sq. ft. office | HealthTech Assist offers integrated digital solutions and IT support for small healthcare practices. Its franchise model emphasizes efficiency and cost savings through advanced technology. |
Total Count
This updated guide now includes exactly 80 healthcare franchise opportunities across eight categories (10 per category).
Conclusion & Industry Trends
The U.S. healthcare franchise industry continues to evolve and expand as consumer demand shifts toward convenient, on-demand services and personalized care. Franchises in urgent care, home healthcare, wellness, diagnostics, and retail health offer diverse opportunities—from high-capital, full-service clinics to low-cost, home-based consulting operations. Key trends include the rise of membership-based revenue models, integration of advanced technology (telehealth, digital management systems), and a focus on quality care in an aging population. Entrepreneurs can leverage these proven systems, robust training, and national marketing support to successfully enter a dynamic market that combines financial opportunity with community impact.
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